|
Sign In to gain access to subscriptions and/or personal tools.
|
Combining Distribution- and Anchor-Based Approaches to Determine Minimally Important Differences
The FACIT Experience
Kathleen J. Yost
Evanston Northwestern Healthcare Research Institute
David T. Eton
Evanston Northwestern Healthcare Research Institute
Health-related quality of life (HRQOL) is an important endpoint in cancer clinical trials and in cancer treatment in general; however, the meaningfulness of HRQOL scores may not be apparent to clinicians or researchers. Minimally important differences (MIDs) can enhance the interpretability of HRQOL scores by identifying differences likely to be meaningful to patients and clinicians. This article’s objective is to describe and provide examples of approaches we have used to identify MIDs for instruments in the Functional Assessment of Chronic Illness Therapy (FACIT) measurement system. Distribution- and anchor-based approaches are described and illustrated. We also discuss the importance of assessing the appropriateness of anchors, and we provide suggestions for combining results into a single range of plausible MIDs. MIDs for FACIT instruments established to date are summarized, and general guidelines that can be used to estimate MIDs for other FACIT instruments are provided. Applications of MIDs in research are illustrated.
Key Words: health-related quality of life • cancer • minimally important difference • clinical significance
Evaluation & the Health Professions, Vol. 28, No. 2,
172-191 (2005)
DOI: 10.1177/0163278705275340
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
A. B. Kornblith, H. Q. Huang, J. L. Walker, N. M. Spirtos, J. Rotmensch, and D. Cella
Quality of Life of Patients With Endometrial Cancer Undergoing Laparoscopic International Federation of Gynecology and Obstetrics Staging Compared With Laparotomy: A Gynecologic Oncology Group Study
J. Clin. Oncol.,
November 10, 2009;
27(32):
5337 - 5342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. L. Nelson, L. B. Wenzel, K. Osann, A. Dogan-Ates, N. Chantana, A. Reina-Patton, A. K. Laust, K. P. Nishimoto, A. Chicz-DeMet, N. du Pont, et al.
Stress, Immunity, and Cervical Cancer: Biobehavioral Outcomes of a Randomized Clinical Trail
Clin. Cancer Res.,
April 1, 2008;
14(7):
2111 - 2118.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Bishop, J. L. Beaumont, E. A. Hahn, D. Cella, M. A. Andrykowski, M. J. Brady, M. M. Horowitz, K. A. Sobocinski, J. D. Rizzo, and J. R. Wingard
Late Effects of Cancer and Hematopoietic Stem-Cell Transplantation on Spouses or Partners Compared With Survivors and Survivor-Matched Controls
J. Clin. Oncol.,
April 10, 2007;
25(11):
1403 - 1411.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. B. Wenzel, H. Q. Huang, D. K. Armstrong, J. L. Walker, and D. Cella
Health-Related Quality of Life During and After Intraperitoneal Versus Intravenous Chemotherapy for Optimally Debulked Ovarian Cancer: A Gynecologic Oncology Group Study
J. Clin. Oncol.,
February 1, 2007;
25(4):
437 - 443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Steel, D. T. Eton, D. Cella, M. C. Olek, and B. I. Carr
Clinically meaningful changes in health-related quality of life in patients diagnosed with hepatobiliary carcinoma
Ann. Onc.,
February 1, 2006;
17(2):
304 - 312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Hahn, B. Holzner, G. Kemmler, B. Sperner-Unterweger, S. A. Hudgens, and D. Cella
Cross-Cultural Evaluation of Health Status Using Item Response Theory: FACT-B Comparisons Between Austrian and U.S. Patients With Breast Cancer
Eval Health Prof,
June 1, 2005;
28(2):
233 - 259.
[Abstract]
[PDF]
|
|
|
|
|
