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Evaluation & the Health Professions
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Changes in Surrogate Laboratory Markers, Clinical Endpoints, and Health-Related Quality of Life in Patients Infected with the Human Immunodeficiency Virus

Kitty S. Chan

Dennis A. Revicki

Center for Health Outcomes Research, MEDTAP International

Objective: To evaluate the relationship between laboratory markers of HIV, AIDS- defining events, study discontinuation, and summaryscoresftom theMOS-HWVHealthSurvey. Methods: Secondary analysis of data from a clinical trial of antiretroviral therapies in advanced HIV-infected patients (N = 940). Clinical and health-related quality-of-life data were collected over 48 weeks. Linear regression, logistic regression and survival analyses were performed to evaluate the relationships between MOS-HlVsummary scores, clinical events, and laboratory markers. Results: Each point increase in PHS resulted in a 3.0% decrease in the likelihood of developing an AIDS-defining event (p<.05) and a 2.7% decrease in likelihood of study discontinuation (p<.05). MHS did not significantly predict clinical events, but did predict study discontinuation (p<.05). From the linear regression analyses, the change in CD4 counts was a significant predictor of the change in MHS (p<.01).

Conclusion: The MOS-HIV summary scores predict clinical events and study discontinuation in advanced HIV-infected patients.

Evaluation & the Health Professions, Vol. 21, No. 2, 265-281 (1998)
DOI: 10.1177/016327879802100207
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This article has been cited by other articles:


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Prolongation and quality of life for HIV-infected adults treated with highly active antiretroviral therapy (HAART): a balancing act
J. Antimicrob. Chemother., March 1, 2008; 61(3): 469 - 473.
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